“Glycolysis, Warburg effect, and tumor metabolic flexibility

Authors

  • Óscar H Martínez Costa Spain

Keywords:

Glicosis, Warburg, Flexibilidad metabólica , tumoral

Abstract

Enhanced glycolysis is a feature classically described in tumors. Some cancer cells show conversely an inhibition of this pathway, a phenomenon which relies on the interaction with other highly glycolytic cells of the tumor or the stroma. The metabolic adaptations of cancer provide new diagnostic and therapeutic opportunities.

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References

Fothergill-Gilmore LA, Michels PAM (1993) Evolution of glycolysis. Prog Biophys Mol Biol. 59, 105–235.

Warmoes MO, Locasale JW (2014) Heterogeneity of glycolysis in cancers and therapeutic opportunities. Biochem Pharm. 92, 12-21.

Ghesquière B, Wong BW, Kuchnio A, Carmeliet P (2014) Metabolism of stromal and immune cells in health and disease. Nature 511, 167-176.

Martinez-Outschoorn U, Sotgia F, Lisanti MP (2014) Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function. Semin Oncol. 41, 195-216.

Yeung SJ, Pan J, Lee MH (2008) Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer. Cell Mol Life Sci. 65, 3981-3999.

Obre E, Rossignol R (2015) Emerging concepts in bioenergetics and cancer research: Metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy. Int J Biochem Cell Biol. 59, 167-181

Published

2015-03-21

How to Cite

Martínez Costa, Óscar H. (2015). “Glycolysis, Warburg effect, and tumor metabolic flexibility. Encuentros En La Biología, 8(154), 37–40. Retrieved from https://www.revistas.uma.es/index.php/enbio/article/view/18036

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